Several cardiovascular events, including acute myocardial infarction (MI), show well-defined temporal patterns in their occurrence throughout the year, which is characterised by a peak in winter and a trough in…
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Takotsubo syndrome, TS (also known as broken heart syndrome) mimics the presentation of a heart attack. Heart attack shows well-defined temporal patterns in its occurrence throughout the year, which is characterised by a peak in winter and a trough in summer. Our study is the first study to date investigating the seasonal patterns of presentation of TS and heart attack in the Southern Hemisphere. We have demonstrated that the onset of TS differed as a function of season, with the events most frequent in summer and least so in winter. In contrast, incidence of heart attack was highest in winter and lowest in summer. The reasons underlying this seasonal variation observed in TS are still unclear and further studies are needed to investigate the potential link between season variation in TS onset and its underlying cause.
The incidence of myocardial infarction (MI) is characterised by seasonal variation, with a winter peak and summer trough. Takotsubo syndrome (TS) mimics MI, but is thought to have a distinct aetiology and may exhibit a reversed pattern of seasonal variation. This study investigated the seasonal variation in the incidence of TS in comparison to MI.
Two hundred and sixty consecutive patients with TS (95% women, median age 66 years) admitted between March 2004 and December 2016 in the Auckland region of New Zealand were identified. The study population was grouped into three-month intervals (seasons) according to the date of admission to analyse for potential seasonal variations in the incidence. The TS cohort was compared with 36,376 patients who presented with acute MI in the Auckland region (40% women, median age 71 years) between March 2004 and December 2016.
The onset of TS differed as a function of season (p=0.02), with the events most frequent in summer (n=77, 30%) and least so in winter (n=46, 18%). In contrast, incidence of MI also varied by season (p=0.0003), with highest events in winter and lowest in summer.
The pattern of seasonal variation in TS is reversed compared with MI, with peaks during summer.