1st December 2017, Volume 130 Number 1466

Venkatesh Vaidyanathan, Nishi Karunasinghe, Vetrivhel Krishnamurthy, Chi Hsiu-Juei Kao, Vijay Naidu, Radha Pallati, Alice Wang, Khanh Tran, Prasanna Kallingappa, Anower Jabed, Syed M Shahid, Jonathan Masters, Clare Wall, Ajit Narayanan, Lynnette R Ferguson

Prostate cancer (PCa) is one of the most significant non-skin cancer male health concerns worldwide,1 with at least one in six PCa patients estimated at being at risk of developing aggressive PCa.2 This makes the identification of a strong predictive biomarker and/or treatment of this disease a priority, especially from the New Zealand perspective. The Australia/New Zealand region records the highest rates for age-standardised men with PCa, relative to the population of men worldwide.2,3

Although age, ethnicity and family history are among the most widely accepted risk factors for PCa, nothing concrete has yet been achieved to clinically alter the outcome.4 Other basic underlying components that connect these three factors remain lifestyle and nutrition. With progressing age, lifestyle changes; different individuals across various ethnicities enjoy different kinds of lifestyle; and certain families also have very personalised lifestyle factors, such as the amount and kind of meat eaten. Environmental factors play a major role in the expression of genes and the encoded proteins. Hence, work was started in identifying the most relevant external conditions in New Zealand for their potential effects on the high incidence rate of aggressive PCa.1,4–7

There are certain environmental, nutritional and lifestyle conditions prevalent in New Zealand, such as low levels of selenium in soil,8 deficiency of Vitamin D,9 high intake of fatty foods10 and rate of obesity,11 high percentage of tobacco smokers11 and ageing population12 that may combine in as yet unknown ways to increase the risk of aggressive PCa locally. We have been undertaking a holistic approach to understand the gene by environment interaction(s) and the risk of aggressive PCa in a cohort including New Zealand men of self-declared European ethnicity with different clinically diagnosed grades/stages of PCa, and gender matched healthy controls within a similar age range (Ethics reference NTY05/06/037 by Northern B Ethics Committee, New Zealand, previously, Northern Y Ethics Committee, New Zealand).

Our results have identified a number of single nucleotide polymorphisms (SNPs) statistically significantly associated with a risk of PCa and aggressive PCa. SNPs are increasingly becoming strong biomarker candidates to identify susceptibility of PCa (among other cancers).4 Very interestingly, a number of these genes are related directly and/or indirectly to selenium metabolism, Vitamin D metabolism, obesity and fat metabolism, inflammation and inflammatory pathways, metabolism of tobacco constituents as well as being involved with androgen metabolism, mismatch repair and oncogenesis. PCa is a common but complex disease, involving a number of aspects of genetics such as failure of mismatch repair genes and over-expression of oncogenes, but it will be naïve to forget about the impact of external factors. Current research focus is on the identification of potential and universal biomarkers for aggressive PCa. But it is also well established that we are what we eat, and local external factors such as consumption of red meat, duration of exercise and consumption of dietary supplements will need to be examined. This will aid us in understanding how the progression of PCa can be checked; especially bearing in mind the prevalent health and lifestyle factors in New Zealand.

Although genome-wide association studies are used for the identification of the direct role SNP association plays as risk for aggressive PCa,13 and the various environmental conditions mentioned above have also been related to various non-communicable health diseases,14–16 our results indicate that SNP interactions with demographic and lifestyle factors could also add to the allelic effect of producing a modified risk of a disease.1,5,17,18 Those SNPs that have come up statistically significantly associated with the risk of aggressive PCa in our studies could be indicating a unique situation for New Zealand men with PCa.5 Our belief now is that a uniform multifactor approach will add value towards current clinical practices in improving diagnosis and along with detailed patient history is vital for combatting certain cases of aggressive PCa, which may be influenced by region-specific lifestyle factors as well as of universal genetic factors. In other words, some SNPs important for the progression of PCa may be triggered by local conditions. It is possible that local conditions also play a part for other chronic diseases as well.

The nature of PCa onset is being unraveled with further development of techniques for genomic analysis, with greater access through affordability and accuracy being key drivers of this trend. We propose that the model of patient health should unite the nature and nurture of pathologies in patients equally, and thus the risk of cancers, including PCa, should be region-specific rather than global to take into account local external factors. By identifying such local factors, preventative education programs can also be started to help reduce the risk of PCa as well as encourage early diagnosis of PCa before it becomes aggressive. Such programs may vary from population to population, taking into account lifestyle and nutritional differences. To conclude, we believe that physicians, nutritionists and dieticians, researchers, geneticists and statisticians should be “united” in their approach to tackling PCa, which is to discuss and follow preventative measures on a local, “divided” basis.

Abstract

Prostate cancer is an important health burden to the healthcare system of any country. However, with the current prostate-specific antigen biomarker having low predictive value even for diagnostic purposes, the challenge is still open to tackle this chronic disease. There have been a number of studies which have indicated and encouraged a multi-directional approach to combat this disease. We have been carrying out a multi-directional approach in order to identify certain New Zealand-specific factors which may be drivers for this cancer and its aggressive forms. These will be explained in further detail in this research letter.

Author Information

Venkatesh Vaidyanathan, Teaching Assistant, Department of Molecular Medicine and Pathology, FM & HS, University of Auckland, Auckland; Nishi Karunasinghe, Research Fellow, Auckland Cancer Society Research Centre, Auckland; Vetrivhel Krishnamurthy, Post-Graduate student, University of Auckland, Auckland; Chi Hsiu-Juei Kao, PhD student, Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland; Vijay Naidu, PhD student, School of Engineering, Computer and Mathematical Sciences, Auckland University of Technology, Auckland; Radha Pallati, Laboratory Technician, Auckland Clinical Studies, Auckland; Alice Wang, FM & HS, University of Auckland, Auckland;
Khanh Tran, PhD student, Department of Molecular Medicine and Pathology, FM & HS, University of Auckland, Auckland; Prasanna Kallingappa, Research Fellow, Vernon Jenson Unit, FM & HS, University of Auckland, Auckland; Anower Jabed, Research Fellow, Department of Molecular Medicine and Pathology, FM & HS, University of Auckland, Auckland; Syed M Shahid, Postdoctoral Academic Visitor, FM & HS, University of Auckland, Auckland; Jonathan Masters, Urologist, Urology Department, Auckland District Health Board, Auckland; Clare Wall, Head of Department, Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland; Ajit Narayanan, Head of the Research, School of Engineering, Computer and Mathematical Sciences, Auckland University of Technology, Auckland; Lynnette R Ferguson, Emeritus Professor, University of Auckland, Auckland.

Correspondence

Dr Venkatesh Vaidyanathan, Teaching Assistant, Department of Molecular Medicine and Pathology, FM & HS, University of Auckland, Auckland 1023.

Correspondence Email

v.vaidyanathan@auckland.ac.nz

Competing Interests

Nil.

References

  1. Vaidyanathan V, Naidu V, Kao CH-J, et al. Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach. Mol Biosyst 2017; 13:681–98.
  2. Prostate Cancer-Estimated Incidence, Mortality and Prevalence Worldwide in 2012. International Agency for Research on Cancer, 2012. (Accessed 19/09/2017, at http://globocan.iarc.fr/old/FactSheets/cancers/prostate-new.asp).
  3. Ministry of Health. Cancer: New registrations and deaths 2013. Wellington, New Zealand; 2016.
  4. Vaidyanathan V, Naidu V, Karunasinghe N, et al. Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population. Mol Biosyst 2017;7.
  5. Vaidyanathan V, Naidu V, Karunasinghe N, et al. SNP-SNP interactions as risk factors for aggressive prostate cancer. In: F1000Research; 2017.
  6. Karunasinghe N, Han DY, Zhu S, et al. Effects of supplementation with selenium, as selenized yeast, in a healthy male population from New Zealand. Nutr Cancer 2013; 65:355–66.
  7. Karunasinghe N, Lange K, Yeo Han D, et al. Androgen Pathway Related Gene Variants and Prostate Cancer Association in Auckland Men. Current Pharmacogenomics and Personalized Medicine 2013; 11:22–30.
  8. Hewitt A, Dymond J. Survey of New Zealand soil orders. Ecosystem services in New Zealand: conditions and trends 2013:121–31.
  9. Ministry of Health. Vitamin D Status of New Zealand Adults; 2012.
  10. University-of-Otago-and-Ministry-of-Health. A Focus on Nutrition: Key findings of the 2008/09 New Zealand Adult Nutrition Survey: Wellington: Ministry of Health. 2011.
  11. Ministry-of-Health. Annual Update of Key Results 2014/15: New Zealand Health Survey. Wellington: Ministry of Health; 2015.
  12. Cornwall J, Davey J. Impact of population ageing in New Zealand on the demand for health and disability support services, and workforce implications. Wellington, New Zealand: Ministry of Health; 2004.
  13. Turner AR, Kader AK, Xu J. Utility of Genome-Wide Association Study findings: prostate cancer as a translational research paradigm. J Intern Med 2012; 271:344–52.
  14. Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014; 384:755–65.
  15. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266–81.
  16. Moosmann B, Behl C. Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway. Trends Cardiovasc Med 2004; 14:273–81.
  17. Karunasinghe N, Han DY, Goudie M, et al. Prostate Disease Risk Factors among a New Zealand Cohort. Journal of Nutrigenetics and Nutrigenomics 2013; 5:339–51.
  18. Karunasinghe N, Han DY, Zhu S, et al. Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand. Genes & Nutrition 2012; 7:179–90.