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The New Zealand Medical Journal

 Journal of the New Zealand Medical Association, 06-June-2008, Vol 121 No 1275

A rare cause of stroke
Adriano R Tonelli
A 29-year-old African-American woman with a history of cerebrovascular accident presented with new onset right hemiparesis. On physical examination, digital clubbing (Figures 1 and 2), left-sided weakness with spasticity (Figure 2), and upper lip telangectasia (Figure 1) were noted. Chest radiography and computed tomography of the chest were performed (Figures 3 and 4).

Figure 1. Upper lip mucosa telangectasia and digital clubbing


Figure 2. Digital clubbing and hand spasticity with muscle contractures

Figure 3. Postero-anterior chest radiography


Figure 4. Computed tomography (CT) of the chest with contrast

What is the diagnosis?
Author information: Dr Adriano R Tonelli. Pulmonary and Critical Care Fellow, University of Florida, Gainesville, Florida, USA
Correspondence: Dr Adriano Tonelli, Health Science Center, 1600 SW Archer Road, Room M452, Gainesville, Florida, USA. Fax: +1 (0)352 3920821; email: Adriano.Tonelli@medicine.ufl.edu
References:
  1. Shovlin CL, Guttmacher AE, Buscarini E, et al. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet. 2000;91:66–7.
  2. Cottin V, Dupuis-Girod S, Lesca G, et al. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler disease). Respiration. 2007;74:361–78.
  3. Begbie ME, Wallace GM, Shovlin CL. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century. Postgrad Med J. 2003;79:18–24.
  4. Bayrak-Toydemir P, Mao R, Lewin S, McDonald J. Hereditary hemorrhagic telangiectasia: an overview of diagnosis and management in the molecular era for clinicians. Genet Med. 2004;6:175–91.
  5. Moussouttas M, Fayad P, Rosenblatt M, et al. Pulmonary arteriovenous malformations: cerebral ischemia and neurologic manifestations. Neurology. 2000;55:959–64.
     
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