Recent reports indicate that the best results in hay fever are obtained from the exhibition of very weak solutions of adrenalin frequently repeated. In the International Medical Magazine, July 1903, page 404, Dr E.B. Gleason of Philadelphia says, “The patient may also spray the nose every hour or two, if necessary, with a solution of adrenalin hydrochlorate in the strength of 1 to10,000 or 1 to 20,000. When the writer first began using this drug his results were not altogether satisfactory. Temporary relief was always obtained to a greater or less extent, but the use of the stronger solutions was always followed by a reaction similar to that of cocaine-solutions. The results have been vastly better since very dilute solutions at frequent intervals have been employed."

Dr George L. Richards, chairman of the Eastern Section of the American Laryngological, Rhinological, and Otological Society, directs attention to the above in a private communication, and says, “It has been my own experience that very weak solutions, repeated as needed, work very much better than the stronger ones, and I have found a solution as weak as 1-16,000 to answer very well – that is, I order

1 drachm of the 1-1000 solution with sufficient of the diluting medium to make 2 ounces.” To make a 1-10,000 solution of adrenalin chloride, take one part of adrenalin chloride solution 1-1,000 to nine parts of distilled water or normal salt solution. To prepare a 1-20,000 solution, of course double the quantity of diluent is required.

Busy practitioners will find Messrs. Parke, Davis, and Co’s compressed tablets No.365 of great convenience in the preparation of normal salt solution; one of these dissolved in 4 oz of water provides normal salt solution, which is preferable to distilled water as a diluting medium.

We have pleasure in drawing attention to the new sweetmeat, or rather, food, which has been recently put on the market by Messrs Cadbury. Milk chocolate is at once a most pleasant as well as a nourishing article.