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Early diagnosis and treatment in psychotic disorders: an
achievable healthcare reform strategy
Patrick McGorry
In most societies, the treatment of mental disorders and
mental health problems is a low priority.1 Even
in affluent nations, and even though they are the major cause of non-fatal
disability,2 the coverage of these disorders by
the health system is poor.5 Only a fraction of
those with so-called high prevalence disorders, such as depression and anxiety,
receive any treatment at all—while even those with lower-prevalence, more
severe disorders (such as schizophrenia and bipolar disorder) typically obtain
intermittent care of substandard quality, overly focused on acute episodes.
Mental healthcare is predominantly reactive, and often
unnecessarily iatrogenic as a result. Stigma, prejudice, and ignorance combine
to maintain a silence throughout the community, which (until recently) allowed
this neglect to continue. Pervasive therapeutic nihilism, especially regarding
psychotic disorders like schizophrenia, has undermined efforts to reduce the
human and economic costs of these illnesses. Consequently, preventive thinking
and early diagnosis has been unable to germinate or flourish in this hostile
environment (until recently).
However, over the past decade, we have seen this situation
begin to transform. With the advent of new treatments, new service models and
increased visibility of mental health problems within the community, the early
intervention paradigm has gained momentum
internationally.4 So, for the first time, the
principles of early diagnosis and phase-specific treatment have been applied to
potentially serious mental disorders.
The notion—if a disease is serious and that effective
treatments exist, then the diagnosis should be made at the earliest point
possible—is compelling. Indeed, in cancer, heart disease, and other
serious medical illnesses, it has been pursued vigorously with positive effects
on morbidity and mortality. Staging is a related idea, which proposes that the
specific content or mix of treatments will differ according the stage of
development of the disease, as will both the efficacy and the risks of
treatment. There are many challenges raised in attempting early
diagnosis,3 and these are made more complex in
psychiatry by the lack of tests or markers of our diagnostic syndromes.
Nevertheless, the worldwide
experience6 of this reform-process demonstrates
several things. Firstly, that the available evidence supports its continued
expansion.7 It is even proving feasible to
identify and treat some patients in the pre-psychotic or prodromal phase of
schizophrenia.8 Secondly, that it represents a
realistic way forward for improved morale and workforce development—and
better quality within mental health services. Treatment success, which is
readily achievable at this stage, challenges therapeutic nihilism and can
inspire confidence in mental healthcare, something that is in short supply as a
result of the severe rationing of resources and all that flows from this.
Thirdly, the success of the early psychosis paradigm may lead to a more
substantial reform of healthcare—so that the major peak in incidence and
prevalence in adolescence and early adulthood for a whole range of mental and
substance-use disorders can be responded to in a cohesive, logical, and
acceptable manner within a youth health model.9
Finally, a clinical focus on onset and early course is also likely to facilitate
neuroscientific advances in
knowledge.10
New Zealand (like Canada, the UK, and Scandinavia) has
established growth points for this reform process in many centres (as a result
of outstanding clinical leadership and a national commitment to better outcomes
in mental health). Sustained and extended structural reform, as engineered in
many places, is essential. This means a streamed system of care for young people
with early psychosis—focused on detection, engagement and expert
intervention during the first few years post-onset, which is known as the
critical period.11
However, such a stream of care must have links with yet be
distinct from standard adult psychiatric
services.12 If this does not occur,
international experience shows that no sustained change in approach or quality
results. Special models of primary care are also required to feed and work in
synergy with such a strengthened specialist model. Ultimately, this type of
reform could result in better health care for young people with any kind of
potentially serious mental health problem, not only a psychosis. At the present
time, it represents the best buy in mental health service development
internationally.
Author information:
Patrick D. McGorry, Professor of Psychiatry, University of Melbourne,
Melbourne, Australia
Correspondence:
Patrick D. McGorry, Professor/Director,
ORYGEN Youth Health, Locked Bag 10, Parkville, Victoria. 3052, Australia.
Fax: +61 3 0342 2948; email: mcgorry@ariel.ucs.unimelb.edu.au
References:
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