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The New Zealand Medical Journal

 Journal of the New Zealand Medical Association, 26-September-2003, Vol 116 No 1182

Direct-to-consumer advertising is more profitable if it is misleading
In his editorial about direct-to-consumer advertising, Saunders asked ‘Does DTCA compromise or improve patient health?’ (http://www.nzma.org.nz/journal/116-1180/557/).1 The answer is that there is evidence of increased costs and damage to decision making but no evidence of health benefits.2,3 One of the main problems is that DTCA is more profitable if it is misleading.
For example, the current fluticasone (Flixotide) DTCA creates a misleading impression of effectiveness by using subjective improvement rates without a comparison group.4 The advertisement does not explain that Flixotide is more expensive than appropriate doses of the alternatives. It contains no warnings against unnecessary high doses. It fails to disclose the uncertainty regarding whether or not Flixotide’s higher bioavailability may lead to more long-term adverse effects.5
Another example is the DTCA claiming that tolterodine (Detrusitol) is an ‘effective treatment’. This claim is not supported by the findings of a high-quality systematic review from New Zealand, which shows that apart from causing dry mouth the effects of anticholinergic drugs, including tolterodine, are of questionable clinical significance.6,7
It would be foolish for drug companies to deliberately produce misleading DTCA during the government review. Consequently, it is likely that GlaxoSmithKline and Pharmacia are genuinely unaware that their advertising is misleading. Clearly the sales-promotion culture within drug companies is contrary to producing the balanced educational information that the public needs for good healthcare decisions. The only effective option is to ban DTCA.
Peter R Mansfield
Director, Healthy Skepticism
Willunga, SA, Australia
Barbara Mintzes
Graduate Researcher, Centre for Health Services and Policy Research
University of British Columbia, Vancouver, Canada

References:
  1. Saunders B. Direct-to-consumer advertising – where does the public interest lie? NZ Med J 2003;166(1180). URL: http://www.nzma.org.nz/journal/116-1180/557/
  2. Can drug advertising make you healthier? Finding the answer is not so easy, reports Ipsos PharmTrends. Media release from Ipsos PharmTrends, August 21, 2003. Available online. URL: http://www.ipsos-pa.com/dsp_displaypr_us.cfm?id_to_view=1885 Accessed September 2003.
  3. Toop L, Richards D, Dowell T, et al. Direct to consumer advertising of prescription drugs in New Zealand: for health or for profit? Report to the Minister of Health supporting the case for a ban on DTCA. Dunedin: University of Otago; 2003. Available online. URL: http://www.chmeds.ac.nz/report.pdf Accessed September 2003.
  4. GlaxoSmithKline. Flixotide advertisement. North & South. February 2003.
  5. Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch Intern Med 1999;159:941–55.
  6. Pharmacia. Detrusitol advertisement. Family Health Diary. March/April 2003.
  7. Herbison P, Hay-Smith J, Ellis G, Moore K. Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review. BMJ 2003;326:841–4.


     
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